Publications

(Preprint 1) Dzeng, Y.-C.; Bode, J. W. external page Dynamic Amide Formation by Reversible Nitrone Exchange of Potassium Acyltrifluoroborates (KATs) and Hydroxylamines in Aqueous Conditions ChemRxiv 2021  

(Preprint 2) Ninomiya, M.; Egholm, C.; Breu, D.; Boyman, O.; Bode, J. W. external page In vitro and in vivo Evaluation of Chemically Synthesized, Receptor-Biased Interleukin-4 and Photocaged Variants ChemRxiv 2024. 

(Preprint 3) Götz, J.; Richards, E.; Stepek, I. A.; Takahashi, Y.; Huang, Y.-L.; Bertschi, L.; Rubi, B.; Bode, J. W. external page Predicting Three-Component Reaction Outcomes from 40k Miniaturized Reactant Combinations ChemRxiv 2024. 

(220) Fracassi, A.; Qiao, H.; Lowell, A. N.; Coa, J.; Bode, J. W.; Masai, H.; Yoshizawa-Sugata, N.; Zhou, R.; Yamakoshi, Y. external page Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques ACS Pharmacol. Transl. Sci. 2025, 8, 578-591.

(219) Muhar, M. F.; Farnung, J.; Cernakova, M.; Hofmann, R.; Henneberg, L. T.; Pfleiderer, M. M.; Deonth-Lippuner, A.; Kalcic, F.; Nievergelt, A. S.; Al-Bayati, M. P.; Sidiropoulos, N. D.; Beier, V.; Mann, M.; Jessberger, S.; Jinek, M.; Schulman, B. A.; Bode, J. W.; Corn, J. E. external page C-terminal amides mark proteins for degradation via SCF–FBXO31 Nature 2025, 638, 519-521.

Preprint: external page https://doi.org/10.1101/2023.06.29.547030v1

(218) Wang, J.; Beyer, D.; Vaccarin, C.; He, Y.; Tanriver, M.; Benoit, R.; Deupi, X.; Mu, L.; Bode, J. W.; Schibli, R.; Müller, C. external page Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2 EJNMMI 2024, 52, 9-21.

Preprint: external page https://doi.org/10.1101/2024.03.20.585792

(217) Padhi, C.; Field, C. M.; Forneris, C. C.; Olszewski, D.; Fraley, A. E., Sandu, I.; Scott, T. A.; Farnung, J.; Ruscheweyh, H.-J.; Panda, A. N.; Oxenius, A.; Greber, U. F.; Bode, J. W.; Sunagawa, S.; Raina, V.; Suar, M.; Piel, J. external page Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member PNAS 2024, 121, 49.

(216) Konopka, A.; Coin, G.; Nichols, P. L.; Wanner, B. M. Bode, J. W.; external page Capsules for Automated Azide-Alkyne Click Reactions Org. Lett. 2024, ASAP Articles.

(215) Jiang, T.; Coin, G.; Bordi, S.; Nichols, P. L.; Bode, J. W.; Wanner, B. M. external page Automated Synthesis for the Safe Production of Organic Azides from Primary Amines J. Org. Chemistry 2024, ASAP Articles.

(214) Song, H.; Mikami, T.; Majima, S.; Bode, J. W. external page Atomic Tailoring of Ubiquitin Side Chains Influences E2-Mediated Ubiquitin Chain Formation Helv. Chim. Acta 2024, e202400003.

Preprint: external page https://doi.org/10.26434/chemrxiv-2023-26rl0

(213) Gazzi, T.; Heinke, M.; Landolt, F.; Bode, J. W. external page Chemical Synthesis of Secretoglobin 3A2 Covalent Homodimer and Photocaged Monomeric Variantsexternal page external page  Angew. Chem. Int. Ed. 2024, e202404992.

(212) Weidner, P.; Saar, D.; Söhn, M.; Schroeder, T.; Yu, Y.; Zöllner, F. G.; Ponelies, N.; Zhou, X.; Zwicky, A.; Rohrbacher, F. N.; Pattabiraman, V. R.; Tanriver, M.; Bauer, A.; Ahmed, H.; Ametamey, S.M.; Riffel, P.; Seger, R.; Bode, J. W.; Wade, R. C.;  Ebert, M. P.A.; Kragelund, B. B.; Burgermeister, E. external page Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interactionexternal page  Cancer Letters 2024, 588, 216783.

(211) Tanriver, M.; Müller, M.; Levavsseur, M. D.; Richards, D.; Majima, S.; deMello, A.; Yamauchi, Y.; Bode, J. W. external page Peptide-Directed Attachment of Hydroxylamines to Specific Lysines of IgG Antibodies for Bioconjugations with Acylboronates Angew. Chem. Int. Ed. 2024, Early View.

Preprint: external page https://doi.org/10.26434/chemrxiv-2023-4f6kr

(210) Götz, J.; Jackl, M. K.; Jindakun, C.; Marziale, A. N.; André, J.; Gosling, D. J.; Springer, C.; Palmieri, M.; Reck, M.; Luneau, A.; Brocklehurst, C. E.; Bode, J. W. external page High-Throughput Synthesis Provides Data for Predicting Molecular Properties and Reaction Success. Sci. Adv. 2023, 9, eadj2314.

(209) Mikami T.; Majima S.; Song H.; Bode, J. W. external page Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains. ACS Cent. Sci. 2023, ASAP Article.

Preprint: external page https://doi.org/10.26434/chemrxiv-2023-hlk3f

(208) Farnung, J.; Muhar, M.; Liang, J. R.; Tolmachova, K. A.; Benoit, R. M.; Corn, J. E.; Bode, J. W. external page Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3. ACS Cent. Sci. 2023, 9, 1025-1034.

Preprint: external page https://doi.org/10.1101/2022.08.02.502437

(207) Coin, G.; Jiang T.; Bordi, S.; Nichols, P. L.; Bode, J. W.; Wanner, B.  external page Automated, Capsule-Based Suzuki–Miyaura Cross Couplings.external page  Org. Lett. 2023, ASAP Article.

(206) Beyer, D.; Vaccarin, C.; Deupi, X.; Mapanao, A. K.; Cohrs, S.; Sozzi-Guo, F.; Grundler, P. V.; van der Meulen, N. P.; Wang, J.; Tanriver, M.; Bode, J. W.; Schibli, R.; Müller, C. external page A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides. EJNMMI Research 2023, 13, 32.

(205) Neumann, K.; Vujinovic, A.; Kamara, S.; Baldauf, S.; Bode, J. W. external page Synthesis of Multi-Module Low Density Lipoprotein Receptor Class A Domains with Acid Labile Cyanopyridiniumylides (CyPY) as Aspartic Acid Masking Groups, RSC Chem. Biol. 2023, 4, 292-299.

-Preprint: external page https://doi.org/10.26434/chemrxiv.14482983.v1

(204) Farnung, J.; Tolmachova, K. A.; Bode, J. W. external page Installation of electrophiles onto the C-terminus of recombinant ubiquitin and ubiquitin-like proteins Chem. Sci. 2023, 14, 121-129.

(203) MacMillan, A. E.; Wu, W. W. X.; Nichols, P. L.; Wanner, B. M.; Bode, J. W. external page A Vending Machine for Drug-like Molecules – Automated Synthesis of Virtual Screening Hits Chem. Sci. 2022, 13, 14292-14299.

-Preprint: external page https://doi.org/10.26434/chemrxiv-2022-htpw2

(202) Scott, T. A.; Verest, M.; Farnung, J.; Forneris, C. C.; Robinson, S. L.; Ji, X.; Hubrich, F.; Chepkirui, C.; Richter, D. U.; Huber, S.; Rust, P.; Streiff, A. B.; Zhang, Q.; Bode, J. W.; Piel, J. external page Widespread Microbial Utilization of Ribosomal β-Amino Acid-Containing Peptides and Proteins. Chem 2022, 8, 2659–2677.

(201) Kumarswamyreddy, N.; Nakagawa, A.; Endo, H.; Shimotohno, A.; Torii, K. U.; Bode, J. W.; Oishi, S. external page Chemical Synthesis of the EPF-Family of Plant Cysteine-Rich Proteins and Late-Stage Dye Attachment by Chemoselective Amide-Forming Ligations. RSC Chem. Biol. 2022. https://doi.org/10.1039/D2CB00155A.

(200) Levasseur, M. D.; Hofmann, R.; Edwardson, T. G. W.; Hehn, S.; Thanaburakorn, M.; Bode, J. W.; Hilvert, D. external page Post-Assembly Modification of Protein Cages by Ubc9-Mediated Lysine Acylation. ChemBioChem 2022, e202200332.

(199) Nakamuro, T.; Kamei, K.; Sun, K.; Bode, J. W.; Harano, K.; Nakamura, E. external page Time-Resolved Atomistic Imaging and Statistical Analysis of Daptomycin Oligomers with and without Calcium Ions. J. Am. Chem. Soc. 2022, 144, 13612–13622.

- Preprint: external page doi.org/10.26434/chemrxiv-2022-xdkxs-v2

(198) Tolmachova, K. A.; Farnung, J.; Liang, J. R.; Corn, J. E.; Bode, J. W. external page Facile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM1. ACS Cent. Sci. 2022, 8, 756–762.

(197) Kumarswamyreddy, N.; Reddy, D. N.; Robkis, D. M.; Kamiya, N.; Tsukamoto, R.; Kanaoka, M. M.; Higashiyama, T.; Oishi, S.; Bode, J. W. external page Chemical Synthesis of Torenia Plant Pollen Tube Attractant Proteins by KAHA Ligation. RSC Chem. Biol. 2022, 3, 721–727.

(196) Akimoto, G.; Fernandes, A. P.; Bode, J. W. external page Site-Specific Protein Ubiquitylation Using an Engineered, Chimeric E1 Activating Enzyme and E2 SUMO Conjugating Enzyme Ubc9. ACS Cent. Sci. 2022, 8, 275–281.

(195) Škopić, M. K.; Losch, F.; McMillan, A. E.; Willeke, N.; Malenica, M.; Bering, L.; Bode, J.; Brunschweiger, A. external page Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged Sp3-Rich Heterocycles by SnAP Chemistry. Org. Lett. 2022, 24, 1383–1387.
 

(194) Tung, P.; Schuhmacher, A.; Schilling, P. E.; Bode, J. W.; Mankad, N. external page Preparation of Potassium Acyltrifluoroborates (KATs) from Carboxylic Acids by Copper-Catalyzed Borylation of Mixed Anhydrides. Angew. Chem. Int. Ed. 2022, 61, e202114513.

- Preprint: external page doi.org/10.26434/chemrxiv-2021-jt414

(193) Müller, M.; Gräbnitz, F.; Barandun, N.; Shen, Y.; Wendt, F.; Steiner, S. N.; Severin, Y.; Vetterli, S. U.; Mondal, M.; Prudent, J. R.; Hofmann, R.; van Oostrum, M.; Sarott, R. C.; Nesvizhskii, A. I.; Carreira, E. M.; Bode, J. W.; Snijder, B.; Robinson, J. A.; Loessner, M. J.; Oxenius, A.; Wollscheid, B. external page Light-Mediated Discovery of Surfaceome Nanoscale Organization and Intercellular Receptor Interaction Networks. Nat. Commun. 2021, 12, 7036.

- Preprint: external page doi.org/10.1101/2020.08.11.246652

(192) Tanriver, M.; Dzeng, Y.-C.; Da Ros, S.; Lam, E.; Bode, J. W. external page Mechanism-Based Design of Quinoline Potassium Acyltrifluoroborates for Rapid Amide-Forming Ligations at Physiological pH. J. Am. Chem. Soc. 2021, 143, 17557–17565.

- Preprint: external page doi.org/10.26434/chemrxiv.14474166.v1

(191) Farnung, J.; Song, H.; Bode, J. W. external page Chemical Protein Synthesis by Chemoselective #x03B1;-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline. In: Hussein W.M., Stephenson R.J., Toth I. (eds) Peptide Conjugation. Methods in Molecular Biology, vol 2355. Humana, New York, NY, 2021; pp 151–162.

(190) Fracassi, A.; Ray, A.; Nakatsuka, N.; Passiu, C.; Tanriver, M.; Schauenburg, D.; Scherrer, S.; Ouald Chaib, A.; Mandal, J.; N. Ramakrishna, S.; W. Bode, J.; D. Spencer, N.; Rossi, A.; Yamakoshi, Y. external page KAT Ligation for Rapid and Facile Covalent Attachment of Biomolecules to Surfaces.  ACS Appl. Mater. Interfaces 2021, 13, 29113–29121.

(189) Bhatt, P. R.; Scaiola, A.; Loughran, G.; Leibundgut, M.; Kratzel, A.; Meurs, R.; Dreos, R.; O’Connor, K. M.; McMillan, A.; Bode, J. W.; Thiel, V.; Gatfield, D.; Atkins, J. F.; Ban, N. external page Structural Basis of Ribosomal Frameshifting during Translation of the SARS-CoV-2 RNA Genome. Science 2021, eabf3546.

- Preprint: external page doi.org/2020.10.26.355099

- Highlighted in ETH News

(188) Jiang, T.; Bordi, S.; McMillan, A. E.; Chen, K.-Y.; Saito, F.; Nichols, P. L.; Wanner, B. M.; Bode, J. W. external page An Integrated Console for Capsule-Based, Automated Organic Synthesis. Chem. Sci. 2021, 12, 6977-6982.

- Preprint: external page doi.org/10.26434/chemrxiv.7882799.v1

- Preprint highlighted in external page Nature 2019, 568, 577-​579.

(187) Matabaro, E.; Kaspar, H.; Dahlin, P.; Bader, D. L. V.; Murar, C. E.; Staubli, F.; Field, C. M.; Bode, J. W.; Künzler, M. external page Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A. Sci. Rep. 2021, 11, 3541.

(186) Schuhmacher, A.; Ryan, S. J.; Bode, J. W. external page Catalytic Synthesis of Potassium Acyltrifluoroborates (KATs) from Boronic Acids and the Thioimidate KAT Transfer Reagent. Angew. Chem. Int. Ed. 2021, 60, 3918–3922.

(185) Jackl, M. K.; Gordon, C. P.; Copéret, C.; Bode, J. W. external page Spirocyclic Nitroxide Biradicals: Synthesis and Evaluation as Dynamic Nuclear Polarizing Agents. Helv. Chim. Acta 2020, 3, e2000179.

(184) Song, H.; Wu, D.; Mazunin, D.; Liu, S.M.; Sato, Y.; Broguiere, N.; Zenobi-Wong, M.; Bode, J..W.; external page "Post‐assembly Photomasking of Potassium Acyltrifluoroborates (KATs) for Two‐Photon 3D Patterning of PEG‐Hydrogels", Helv. Chim. Acta. 2020, 103, e2000172.

(183) Hofmann, R.; Akimoto, G.; Wucherpfennig, T. G., Zeymer, C., Bode, J. W.;external page "Lysine Acylation Using Conjugating Enzymes (LACE) for Site-Specific Modification and Ubiquitination of Native Proteins", Nat. Chem. 2020, 12, 1008–1015.

- highlighted in external page Nat. Chem. 2020, 12, 980-982.

- cover picture external page Nat. Chem. 2020, 12(11).

(182) Weidner, P.; Söhn, M.; Schroeder, T.; Helm, L.; Hauber, V.; Gutting, T.; Betge, J.; Röcken, C.; Rohrbacher, F. N.; Pattabiraman, V. R.; Bode, J. W.; Seger, R.; Saar, D.; Nunes-Alves, A.; Wade, R. C.; Ebert, M. P. A.; Burgermeister, E.; external page Myotubularin-Related Protein 7 Activates Peroxisome Proliferator-Activated Receptor-Gamma, Oncogenesis 2020, 9, 59.

(181) Wu, D.; Taguchi, J.; Tanriver, M.; Bode, J..W.; external page Synthesis of Acylboron Compounds. Angew. Chem. Int. Ed. 2020, 59, 16847–16858.

(180) Osuna Gálvez, A.; Bode, J. W.; external page "Synthesis of Amides from Acylboron Compounds" Science of Synthesis Knowledge Updates 2020, 1, 375.

(179) Broguiere, N.; Lüchtefeld, I.; Trachsel, L.; Mazunin, D.; Rizzo, R.; Bode, J. W.; Lutolf, M. P.; Zenobi‐Wong, M.; external page "Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices" Adv. Mater. 2020, 1908299.

(178) Schauenburg, D.; Divandari, M.; Neumann, K.; Spiegel, C.A.; Hackett, T.; Dzeng, Y.; Spencer, N.D.; Bode, J..W.; external page "Synthesis of polymers containing potassium acyltrifluoroborates (KATs) and post‐polymerization ligation and conjugation" Angew. Chem. Int. Ed. 2020, 59, 14656–14663.

(177) Schuhmacher, A.; Shiro, T.; Ryan, S. J.; Bode, J. W.; external page "Synthesis of secondary and tertiary amides without coupling agents from amines and potassium acyltrifluoroborates (KATs)" Chem. Sci. 2020, 11, 7609.

(176) Neumann, K.; Farnung, J.; Baldauf, S.; Bode, J. W.; external page "Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups" Nat. Commun. 2020, 11, 982.

(175) Murar, C. E.; Ninomiya, M.; Shimura, S.;  Karakus, K.; Boyman, O.; Bode, J. W.; external page "Chemical Synthesis of Interleukin‐2 and Disulfide Stabilizing Analogues" Angewandte Chem. Int. Ed. 2020, 59, 8425–8429.

(174) Stepek, I., A.; Hofmann, R.; Nichols, P.; Aschwanden, A.; Eckhard, C.; Aschwanden, P.; Bode, J. W.; external page "Make a Molecule: A Synthetic Organic and Medicinal Chemistry Workshop Program for High School Students" J. Chem. Educ. 2020, 2, 402-413.

(173) Baldauf, S.; Ogunkoya, A. O.; Boross, G. N.; Bode, J. W.; external page "Aspartic Acid Forming α-Ketoacid–Hydroxylamine (KAHA) Ligations with (S)-4,4-difluoro-5-oxaproline" J. Org. Chem. 2020, 3, 1352-1364.

(172) Chiotellis, A.; Ahmed, H.; Betzel, T.; Tanriver, M.; White, C. J.; Song, H.; Da Ros, S.; Schibli, R.; Bode, J. W.; Ametamey, S. M.; external page "Chemoselective ¹⁸F-incorporation into pyridyl acyltrifluoroborates for rapid radiolabelling of peptides and proteins at room temperature" Chem. Commun. 2020, 56, 723-726.

(171) Zhang, Y.; Hirota, T.; Kuwata, K.; Oishi, S.;Gramani, S.G.; Bode, J.W.; external page "Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO–E2–E3 Ligase Ternary Complexes"J. Am. Chem. Soc. 2019, 141, 14742-14751.

(170) Baldauf, S.; Schauenburg, D.; Bode, J. W.; external page "A threonine‐forming oxazetidine amino acid for the chemical synthesis of proteins with the KAHA ligation" Angew. Chem. Int. Ed. 2019, 58, 1–6.

(169) Wang, Y.; Bode, J. W.; external page "Olefin Amine (OLA) Reagents for the Synthesis of Bridged Bicyclic and Spirocyclic Saturated N-Heterocycles by Catalytic HAT Reactions" J. Am. Chem. Soc. 2019, 141, 9739-9745.

(168) Osuna Gálvez, A.; Bode, J. W.; external page "Traceless Templated Amide-Forming Ligations" J. Am. Chem. Soc. 2019, 141, 8721-8726.

(167) Wu, D.; Fohn, N. A.; Bode, J. W.; external page "Catalytic Synthesis of Potassium Acyltrifluoroborates (KATs) byChemoselective Cross-Coupling with a Bifunctional Reagent" Angew. Chem. Int. Ed. 2019, 58, 11058-11062.

(166) Stepek, I. A.; Cao, T.; Koetemann, A.; Shimura, S.; Wollscheid, B.; Bode, J. W.; external page "Antibiotic discovery with synthetic fermentation: library assembly, phenotypic screening, and mechanism of action of beta-peptides targeting penicillin-binding proteins" ACS Chem. Biol. 2019, 14, 1030-1040

(165) Saito, F.; Trapp, N.; Bode, J. W. external page "Iterative Assembly of Polycyclic Saturated Heterocycles from Monomeric Building Blocks" J. Am. Chem. Soc. 2019, 141, 5544–5554

(164) Luescher, M. U.; Bode, J. W. external page "Evidence for a Radical Mechanism in Cu(II)-Promoted SnAP Reactions" Synlett 2019, 30, A–G

(163) Book: Pattabiraman, V. R.; Ogunkoya, A. O.; Bode, J. W. external page "Amide-Forming Ligation Reactions" Organic Reactions (Vol. 97) [Ed: Scott E. Denmark et al.], John Wiley & Sons, Inc.

(162) Baldauf, S.; Bode, J. W. external page "Synthesis and Evaluation of Cyclic Acetals of Serine Hydroxylamine for Amide-Forming KAHA Ligations" Synthesis 2019, 51, A-K

(161) Boross, G. N.; Schauenburg, D.; Bode, J. W. external page "Chemoselective derivatization of folded synthetic insulin variants with potassium acyltrifluoroborates (KATs)" Helv. Chim. Acta 2019, 102, e1800214.

(160) Vagstad, A. L.; Kuranaga, T.; Püntener, S.; Pattabiraman, V. R.; Bode, J. W.; Piel, J. external page "Introduction of D‐Amino Acids in Minimalistic Peptide Substrates by an S‐Adenosyl‐L‐Methionine Radical Epimerase" Angew. Chem. Int. Ed. 2018, 58, 2246-2250

(159) Gu, Y.; Schauenburg, D.; Bode, J. W.; Johnson, J. A. external page "Leaving Groups as Traceless Topological Modifiers for the Synthesis of Topologically Isomeric Polymer Networks" J. Am. Chem. Soc. 2018, 140, 14033–14037

(158) Luescher, M. U.; Jindakun, C.; Bode, J. W. external page "Stannylamine Protocol (SnAP) Reagents for the Synthesis of C–Substituted Morpholines from Aldehydes" Org. Synth. 2018, 95, 357-373

(157) Luescher, M. U.; Jindakun, C.; Bode, J. W. external page "Preparation of Tributyl(iodomethyl)stannane" Org. Synth. 2018, 95, 345-356

(156) Boross, G. N.; Shimura, S.; Besenius, M.; Tennagels, N.; Rossen, K.; Wagner, M.; Bode, J. W. external page "Facile folding of insulin variants bearing a prosthetic C-peptide prepared by α-ketoacid-hydroxylamine (KAHA) ligation"  Chem. Sci. 2018, 9, 8388-8395

(155) Murar, C. E.; Harmand, T. J.; Takano, H.; Bode, J. W. external page "Preparation of (S)-N-Boc-5-oxaproline" Org. Synth. 2018, 95, 157-176

(154) Harmand, T. J.; Murar, C. E.; Takano, H.; Bode, J. W. external page "Enantioselective Synthesis of (S)-Ethyl 2-((tert-butoxycarbonyl)((tert-butyldimethylsilyl)oxy)amino)-4-oxobutanoate" Org. Synth. 2018, 95, 142-156

(153) Schauenburg, D.; Osuna Gálvez, A.; Bode, J. W. external page "Covalently functionalized amide-crosslinked hydrogels from primary amines and polyethylene glycol acyltrifluoroborates (PEG-KATs)" J. Mater. Chem. B 
2018, 6, 4775-4782

(152) Jackl, M.; Schuhmacher, A.; Shiro, T.; Bode, J. W.; external page "Synthesis of N,N-Alkylated α-Tertiary Amines by Coupling of α-Aminoalkyltrifluoroborates and Grignard Reagents" Org. Lett. 2018, 20, 4044–4047

(151) Shiro, T.; Schuhmacher, A.; Jackl, M.; Bode, J. W.; external page "Facile Synthesis of α-Aminoboronic Acids from Amines and Potassium Acyltrifluoroborates (KATs) via Trifluoroborate-Iminiums (TIMs)" Chem. Sci. 2018, 9, 5191-5196
- external page reviewed in Synfacts 2018, 14, 855

(150) Rohrbacher, F.; Zwicky, A.; Bode, J. W.; external page "Facile Synthesis of Internal and C-Terminal Peptide α-Ketoamides with Fmoc-Solid Phase Peptide Synthesis" Helv. Chim. Acta 2018, 101, e1800039

(149) Review article: Stepek, I. A.; Bode, J. W.; external page "Synthetic fermentation of bioactive molecules" Curr. Opin. Chem. Biol. 2018, 46, 18–24

(148) Liu, S. M.; Wu, D.; Bode, J. W.; external page "One-Step Synthesis of Aliphatic Potassium Acyltrifluoroborates (KATs) from Organocuprates" Org. Lett. 2018, 20, 2378–2381

(147) Jindakun, C.; Hsieh, S.-Y.; Bode, J. W.; external page "Iridium-catalyzed Synthesis of Saturated N‐Heterocycles from Aldehydes and SnAP Reagents with Continuous Flow Photochemistry" Org. Lett. 2018, 20, 2071–2075
- external page reviewed in Synfacts 2018, 12, 629 

(146) Hubert, J. G.; Stepek, I. A.; Noda, H.; Bode, J. W.; external page "Synthetic Fermentation of β-peptide Macrocycles by Thiadiazole-Forming Ring-Closing Reactions" Chem. Sci. 2018, 9, 2159–2167 
- external page highlighted in Chimia 2018, 72, 338

(145) White, C. J.; Bode, J. W.; external page "PEGylation and Dimerization of Expressed Proteins under Near Equimolar Conditions with Potassium 2-Pyridyl Acyltrifluoroborates" ACS Cent. Sci. 2018, 4, 197–206

(144) Luescher, M. U.; Songsichan, T.; Hsieh, S.-Y.; Bode, J. W.; external page "Copper Promoted Oxidative Coupling of SnAP Hydrazines and Aldehydes to Form Chiral 1,4,5-Oxadiazepanes and 1,2,5-Triazepanes" Helv. Chim. Acta 2017, 100, e1700199

(143) Taguchi, J.; Ikeda, T.; Takahashi, R.; Sasaki, I.; Ogasawara, Y.; Dairi, T.; Kato, N.; Yamamoto, Y.; Bode, J. W.; Ito, H. external page "Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate"Angew. Chem. Int. Ed. 2017, 56, 13847–13851external page

(142) Review article: Bode, J. W. external page "Chemical Protein Synthesis with the α-Ketoacid–Hydroxylamine Ligation" Acc. Chem. Res. 2017, 50, 2104–2115

(141) Harmand, T. J.; Pattabiraman, V. R.; Bode, J. W. external page "Chemical Synthesis of the Highly Hydrophobic Antiviral Membrane Associated Protein IFITM3 and Modified Variants" Angew. Chem. Int. Ed. 2017, 56, 12639–12643

(140) Jackl, M. K.; Legnani, L.; Morandi, B.; Bode, J. W. external page "Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis" Org. Lett., 2017, 19, 4696–4699
- external page highlighted in Org. Process Res. Dev. 2017, 21, 1453–1463

(139) Rohrbacher, F.; Baldauf, S.; Wucherpfennig, T. G.; Bode, J. W. external page "Product Selectivity in KAHA Ligations: Ester vs. Amide Formation with Cyclic Hydroxylamines" Synlett. 2017, 28, 1929–1933 

(138) Murar, C. E.; Harmand, T. J.; Bode, J. W. external page "Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation" Bioorg. Med. Chem. 2017, 25, 4996–5001

(137) Rohrbacher, F.; Zwicky, A.; Bode, J. W. external page "Chemical Synthesis of a Homoserine-Mutant of the Antibacterial, Head-to-Tail Cyclized Protein AS-48 by α-Ketoacid–Hydroxylamine (KAHA) Ligation" Chem. Sci. 2017, 8, 4051–4055 

(136) Saito, F.; Bode, J. W. external page "Synthesis and stabilities of peptide-based [1]rotaxanes: molecular grafting onto lasso peptide scaffolds" Chem. Sci. 2017, 8, 2878–2884 

(135) Osuna Gálvez, A.; Schaack, C. P.; Noda, H.; Bode, J. W. external page "Chemoselective acylation of primary amines and amides with potassium acyltrifluoroborates under acidic conditions" J. Am. Chem. Soc. 2017, 139, 1826–1829
- external page highlighted in Org. Process Res. Dev. 2017, 21, 279–291

(134) Oriana, S.; Ye, C.; Bode, J. W.; Yamakoshi, Y. external page "Synthesis of tri-functionalized MMP2 FRET probes using a chemo-selective and late-stage modification of unprotected peptides" Org. Biomol. Chem. 2017, 15, 1792-1800

(133) Hsieh, S-.Y.; Bode, J. W. external page "Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents" ACS Cent. Sci. 2017, 3, 66–72

(132) Mazunin, D.; Bode, J. W. external page "Potassium Acyltrifluoroborate (KAT) Ligations are Orthogonal to Thiol-Michael and SPAAC Reactions: Covalent Dual Immobilization of Proteins onto Synthetic PEG Hydrogels" Helv. Chim. Acta 2017, 100, e1600311

(131) Kreituss, I.; Bode, J. W. external page "Flow chemistry and polymer-supported pseudoenantiomeric acylating agents enable parallel kinetic resolution of chiral saturated N-heterocycles" Nature Chem. 2017, 9, 446–452

(130) Review article: Kreituss, I.; Bode, J. W. external page "Catalytic Kinetic Resolution of Saturated N-Heterocycles by Enantioselective Amidation with Chiral Hydroxamic Acids" Acc. Chem. Res. 2016, 49, 2807–2821

(129) Book chapter: Chiang, P.-C.; Bode, J. W. external page "N-Heterocyclic Carbenes as Organic Catalysts" N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools (Edition 2) [Ed: Silvia Diez-Gonzalez]

(128) Perspective: Saito, F.; Bode, J. W. "external page Macrocyclic Peptides: Tying Up Loose Ends" Nature Chem. 2016, 8, 1085-1086

(127) Perspective: Hofmann, R.; Bode, J. W. external page "A Radical Approach to Posttranslational Mutagenesis" Science 2016, 354, 553–554. 

(126) Liu, S. M.; Mazunin, D.; Pattabiraman, V. R.; Bode, J. W.; external page "Synthesis of Bifunctional Potassium Acyltrifluoroborates" Org. Lett. 2016, 18, 5336–5339

(125) Thuaud, F.; Rohrbacher, F.; Zwicky, A.; Bode, J. W.; external page "Photoprotected Peptideα-Ketoacids and Hydroxylamines for Iterative and One-Pot KAHA Ligations: Synthesis of NEDD8" Helv. Chim. Acta 2016, 99, 868–894

(124) Trindade, A. F.; Bode, J. W.; external page "Irreversible Conjugation of Aldehydes in Water To Form Stable 1,2,4-Oxadiazinan-5-ones" Org. Lett. 2016, 18, 4210–4213

(123) Wucherpfennig, T. G.; Müller, S; Wolfrum, C.; Bode, J. W.; external page "Chemical Synthesis of the 12 kDa Human Myokine Irisin byα-Ketoacid-Hydroxylamine (KAHA) Ligation" Helv. Chim. Acta 2016, 99, 897–907

(122) Thuaud, F.; Rohrbacher, F.; Zwicky, A.; Bode, J. W.; external page "Incorporation of Acid-Labile Masking Groups for the Traceless Synthesis of C-Terminal Peptide α-Ketoacids" Org. Lett. 2016, 18, 3670–3673

(121) Harmand, T. J.; Murar, C. E.; Bode, J. W.; external page "Protein chemical synthesis by α-ketoacid-hydroxylamine ligation" Nature Protocols 2016, 11, 1130-1147

(120) Luescher, M. U.; Bode, J. W.; external page "SnAP-eX Reagents for the Synthesis of Exocyclic 3-Amino- and 3-Alkoxypyrrolidines and Piperidines from Aldehydes" Org. Lett. 2016, 18, 2652–2655

(119) Hsieh, S.-Y.; Bode, J. W.; external page "Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones" Org. Lett. 2016, 18, 2098–2101

(118) Jackl, M. K.; Kreituss, I.; Bode J. W.; external page "Synthesis of Tetrahydronaphthyridines from Aldehydes and HARP Reagents via Radical Pictet–Spengler Reactions" Org. Lett. 2016, 18, 1713–1715
- external page reviewed in Synfacts 2016, 12, 0569

(117) Kreituss, I.; Chen, K.-Y.; Eitel, S. H.; Adam, J.-M.; Wuitschik, G.; Fettes, A.; Bode, J. W. external page "A Robust, Recyclable Resin for Decagram Scale Resolution of (±)-Mefloquine and Other Chiral N-Heterocycles" Angew. Chem. Int. Ed. 2016, 55, 1553–1556.
- external page reviewed in Synfacts 2016, 12, 0422. 

(116) Account: Noda, H.; Bode, J. W. external page "Synthesis and Reactivities of Monofluoro Acylboronates in Chemoselective Amide Bond Forming Ligation with Hydroxylamines" Org. Biomol. Chem. 2016, 14, 16–20.

(115) He, C.; Kulkarni, S. S.; Thuaud, F.; Bode, J. W. external page "Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α-Ketoacid-Hydroxylamine (KAHA) Ligation" Angew. Chem. Int. Ed. 2015, 54, 12996–13001.

(114) Wanner, B.; Kreituss, I.; Gutierrez, O.; Kozlowski, M. C.; Bode, J. W. external page "Catalytic Kinetic Resolution of Disubstituted Piperidines by Enantioselective Acylation: Synthetic Utility and Mechanistic Insights" J. Am. Chem. Soc. 2015, 137, 11491–11497.

(113) Review article: Luescher, M. U.; Geoghegan, K.; Nichols, P. L.; Bode, J. W. external page "SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of Saturated N-Heterocycles", Aldrichim. Acta 2015, 48, 43–48.

(112) Luescher, M. U.; Bode, J. W. external page "Catalytic Synthesis of N-Unprotected Piperazines, Morpholines, and Thiomorpholines from Aldehydes and SnAP Reagents" Angew. Chem. Int. Ed. 2015, 54, 10884–10888.
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(111)  Pusterla, I.; Bode, J. W. external page "An oxazetidine amino acid for chemical protein synthesis by rapid, serine-forming ligations" Nature Chem. 2015, 7, 668–672.
- external page reviewed in Synform 2016, 02, A29-A31

(110) Rohrbacher, F.; Deniau, G.; Luther, A.; Bode, J. W. external page "Spontaneous Head-to-Tail Cyclization of Unprotected Linear Peptides with the KAHA Ligation" Chem. Sci. 2015, 6, 4889–4896.

(109) Mazunin, D.; Broguiere, N.; Zenobi-Wong, M.; Bode, J. W. external page "Synthesis of Biocompatible PEG Hydrogels by pH-Sensitive Potassium Acyltrifluoroborate (KAT) Amide Ligations" ACS Biomater. Sci. Eng. 2015, 1, 456–462.

(108) Geoghegan, K.; Bode, J. W. external page "Bespoke SnAP Reagents for the Synthesis of C-Substituted Spirocyclic and Bicyclic Saturated N-Heterocycles" Org. Lett. 2015, 17, 1934–1937.
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(107) Book chapter: Rohrbacher, F.; Wucherpfennig, T. G.; Bode, J. W. external page "Chemical Protein Synthesis with the KAHA Ligation" Top. Curr. Chem. 2015, 363, 1–32.

(106) Noda, H.; Bode, J. W. external page "Synthesis of Chemically and Configurationally Stable Monofluoro Acylboronates: Effect of Ligand Structure on their Formation, Properties and Reactivities" J. Am. Chem. Soc. 2015, 137, 3958–3966.

(105) Harmand, T. J.; Kulkarni, S. S.; Bode, J. W. external page "Optimized Synthesis of a Cyanosulfurylide Linker for Fmoc-SPPS of C-Terminal Peptide α-Ketoacids" Tetrahedron Lett. 2015, 56, 3477–3480.

(104) Saito, F.; Noda, H.; Bode, J. W. external page "Critical evaluation and rate constants of chemoselective ligation reactions for stoichiometric conjugations in water" ACS Chem. Biol. 2015, 10, 1026–1033.
- external page highlighted in Nat. Chem. Biol. 2015, 11, 241.

(103) Schäfer, G.; Leu, L.; Bode, J. W. external page "Synthesis of Unsymmetrical,gem-Disubstituted Bisamides" Heterocycles 2015, 90, 1375–1386. (Special issue)
- Dedicated to Professor Isao Kuwajima on the occasion of his 77th birthday.

(102) Murar, C. E.; Thuaud, F.; Bode, J. W. external page "KAHA Ligations that form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification" J. Am. Chem. Soc. 2014, 136, 18140–18148.

(101) Siau, W.-Y.; Bode, J. W. external page "One Step Synthesis of Saturated Spirocyclic N-Heterocycles with SnAP Reagents and Ketones" J. Am. Chem. Soc. 2014, 136, 17726–17729.
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(100) Review article: Harmand, T. J. R.; Murar, C. E.; Bode, J. W. external page "New chemistries for chemoselective peptide ligations and the total synthesis of proteins" Curr. Opin. Chem. Biol. 2014, 22, 115–121.

(99) Wucherpfennig, T. G.; Pattabiraman, V. R.; Limberg, F. R. P.; Ruiz-Rodríguez, J.; Bode, J. W. external page "Traceless Preparation of C-Terminal α-Ketoacids for Chemical Protein Synthesis by α-Ketoacid–Hydroxylamine Ligation: Synthesis of SUMO2/3" Angew. Chem. Int. Ed. 2014, 53, 12248–12252.

(98) Wucherpfennig, T. G.; Rohrbacher, F.; Pattabiraman, V. R.; Bode, J. W. external page "Formation and Rearrangement of Homoserine Depsipeptides and Depsiproteins in the α-Ketoacid–Hydroxylamine Ligation with 5-Oxaproline" Angew. Chem. Int. Ed. 2014, 53, 12244–12247.
- selected as a Hot Paper.

(97) Huang, Y.-L.; Bode, J. W. external page "Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents" Nature Chem. 2014, 6, 877–884.
- external page highlighted in C&EN.
- external page highlighted in Chemistry World.
- external page Interview: Nature Chem. 2014, 6, 846–847.
- external page highlighted in Nat. Chem. Biol. 2014, 10, 984.

(96) Allen, S. E.; Hsieh, S.-Y.; Gutierrez, O.; Bode, J. W.; Kozlowski, M. C. external page "Concerted Amidation of Activated Esters: Reaction Path and Origins of Selectivity in the Kinetic Resolution of Cyclic Amines via NHC and Hydroxamic Acid Co-Catalyzed Acyl Transfer" J. Am. Chem. Soc.  2014, 136, 11783–11791.

(95) Erős, G.; Kushida, Y.; Bode, J. W. external page "A Reagent for the One-Step Preparation of Potassium Acyltrifluoroborates (KATs) from Aryl- and Heteroarylhalides" Angew. Chem. Int. Ed. 2014, 53, 7604–7607.
- selected as a Hot Paper.
- external page reviewed in Synfacts 2014, 10, 1071. 

(94) Hsieh, S.-Y.; Bode, J. W. external page "(4aR,9aS)-4-Hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one" e-EROS 2014, Published Online. (DOI: 10.1002/047084289X.rn01654)

(93) Noda, H.; Bode, J. W. external page "Synthesis and Chemoselective Ligations of MIDA Acylboronates withO-Me Hydroxylamines" Chem. Sci. 2014, 5, 4328–4332.

(92) Hsieh, S.-Y.; Wanner, B.; Wheeler, P.; Beauchemin, A. M.; Rovis, T; Bode, J. W. external page "Stereoelectronic Basis for the Kinetic Resolution of N-Heterocycles with Chiral Acylating Reagents" Chem. Eur. J. 2014, 20, 7228–7231.

(91) Schäfer, G.; Bode, J. W. external page "The Synthesis of Sterically Hindered Amides" CHIMIA 2014, 68, 252–255.
- On the occasion of the SCS-Metrohm Foundation Award for best oral presentation at the Fall Meeting 2013.

(90) Noda, H; Erős, G; Bode, J. W. external page "Rapid Ligations with Equimolar Reactants in Water with the Potassium Acyltrifluoroborate (KAT) Amide-Formation" J. Am. Chem. Soc. 2014, 136, 5611–5614.
- external page highlighted in C&EN.

(89) Review article: Vo, C.-V.; Bode, J. W. external page "Synthesis of Saturated N-Heterocycles" J. Org. Chem. 2014, 79, 2809–2815.
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(88) Schäfer, G.; Bode, J. W. external page "Synthesis of Sterically HinderedN-Acylated Amino Acids fromN-Carboxyanhydrides" Org. Lett. 2014, 16, 1526–1529.
- external page reviewed in Synfacts 2014, 10, 635.
- external page highlighted in Org. Process Res. Dev. 2014, 18, 562–572. 

(87) Vo, C.-V.; Luescher, M. U.; Bode, J. W. external page "SnAP Reagents for the One-Step Synthesis of Medium Ring Saturated N-Heterocycles from Aldehydes" Nature Chem. 2014, 6, 310–314.
- external page highlighted in C&EN.
- external page highlighted in CHIMIA.
- external page highlighted in Synfacts 2014, 10, A108.
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(86) Luescher, M. U.; Vo, C.-V.; Bode, J. W. external page "SnAP Reagents for the Synthesis of Piperazines and Morpholines" Org. Lett. 2014, 16, 1236–1239.
- external page highlighted in C&EN.
- external page abstracted in ChemInform 2014, published online. (DOI: 10.1002/chin.201432028)
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(85) Review article: Mahatthananchai, J.; Bode, J. W. external page "On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums" Acc. Chem. Res. 2014, 47, 696–707.

(84) Book chapter: Mahatthananchai, J.; Bode, J. W. external page "Catalytic Reactions with N-Mesityl Substituted N-Heterocyclic Carbenes" Contemporary Carbene Chemistry 2013, 237–273. [Eds: Robert A. Moss / Michael P. Doyle]

(83) News and views: Bode, J. W. external page "Carbene catalysis: An internal affair" Nature Chem. 2013, 5, 813–815.

(82) Teichert, J. F.; Mazunin, D.; Bode, J. W. external page "Chemical Sensing of Polyols with Shapeshifting Boronic Acids as a Self-Contained Sensor Array" J. Am. Chem. Soc. 2013, 135, 11314–11321.
- external page highlighted in Spotlights on Recent JACS Publications, J. Am. Chem. Soc. 2013, 135, 11679–11679.

(81) Gondo, C. A.; Bode, J. W. external page "Catalytic Redox Amidations of Aldehydes with a Polymer-Supported Peptide-N-Heterocyclic Carbene Multifunctional Catalyst" Synlett 2013, 24, 1205–1210.
- Cluster Issue on Carbene Catalysis

(80) Vo, C.-V.; Mikutis, G.; Bode, J. W. external page "SnAP Reagents for the Transformation of Aldehydes into Substituted Thiomorpholines—An Alternative to Cross-Coupling with Saturated Heterocycles" Angew. Chem. Int. Ed. 2013, 52, 1705–1708.
- external page highlighted in C&EN.
- SnAP reagents are commercially available on external page SIGMA-ALDRICH!

(79) He, M.; Bode, J. W. external page "E pluribus unum: Isolation, structure determination, network analysis and DFT studies of a single metastable structure from a shapeshifting mixture of 852 bullvalene structural isomers" Org. Biomol. Chem. 2013, 11, 1306–1317.
- external page selected as a cover. Org. Biomol. Chem. 2013, 11, 1262.

(78) Chiang, Y.-L; Russak, J. A.; Carrillo, N; Bode, J. W. external page "Synthesis of Enantiopure Isoxazolidine Monomers for the Preparation of β3-Oligopeptides by Iterative α-Ketoacid–Hydroxylamine (KAHA) Ligations" Helv. Chim. Acta 2012, 2481–2501.
- Dedicated to Professor Dieter Seebach on the occasion of his 75th birthday

(77) He, M.; Rommel, M.; Bode, J. W. external page "Formal Synthesis of (±)-Clausenamide by NHC-Catalyzed γ-Lactam Formation" Heterocycles 2012, 86, 1689–1696. (Special issue)

(76) Book chapter: Mahatthananchai, J.; Bode, J. W. external page "Enantioselective Annulations With Chiral N-Mesityl N-Heterocyclic Carbenes" Asymmetric Synthesis: The Essentials II, 2012, 67–77. [Eds: Christmann, Mathias / Bräse, Stefan]

(75) Review article: Mahatthananchai, J.; Dumas, A. M.; Bode, J. W. external page "Catalytic Selective Synthesis" Angew. Chem. Int. Ed. 2012, 51, 10954–10990.
- Dedicated to Professor Michael P. Doyle on the occasion of his 70th birthday
- external page highlighted in Org. Process Res. Dev. 2013, 17, 160–168.

(74) Kreituss, I.; Murakami, Y.; Binanzer, M.; Bode, J. W. external page "Kinetic Resolution of Nitrogen Heterocycles with a Reusable Polymer-Supported Reagent" Angew. Chem. Int. Ed. 2012, 51, 10660–10663.
- external page highlighted in Org. Process Res. Dev. 2012, 16, 1674–1683.

(73) Book Chapter: Bode, J. W. external page "Reinventing Amide Bond Formation" Top. Organomet. Chem. 2013, 44, 13–33.

(72) Ogunkoya, A. O.; Pattabiraman, V. R.; Bode, J. W. external page "Sequential α-Ketoacid-Hydroxylamine (KAHA) Ligations: Synthesis of C-Terminal Variants of the Modifier Protein UFM1" Angew. Chem. Int. Ed. 2012, 51, 9693–9697.
- external page Corrigendum: Angew. Chem. Int. Ed. 2014, 53, 12005.

(71) Kravina, A. G., Mahatthananchai, J.; Bode, J. W. external page "Enantioselective, NHC-Catalyzed Annulations of Trisubstituted Enals and Cyclic N-Sulfonylimines via α,β-Unsaturated Acyl Azoliums" Angew. Chem. Int. Ed. 2012, 51, 9433–9436.

(70) Schäfer, G.; Matthey, C.; Bode, J. W. external page "Facile Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Isocyanates" Angew. Chem. Int. Ed. 2012, 51, 9173–9175.
- selected as a Hot Paper.

(69) Hsieh, S.-Y.; Binanzer, M.; Kreituss, I.; Bode, J. W. external page "Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles" Chem. Commun. 2012, 48, 8892–8894.
- external page abstracted in ChemInform 2012, published online. (DOI: 10.1002/chin.201249022)

(68) Book chapter: Gondo, C. A.; Bode, J. W. "1,2,4-Triazolium Salts", Science of Synthesis: Houben Weyl Methods of Molecular Transformations, Vol. 13.33, 2012, Georg Thieme Verlag, 199–214. [Ed: B. List]

(67) Allen, S. E.; Mahatthananchai, J.; Bode, J. W.; Kozlowski, M. C. external page "Oxyanion-steering and CH-π Interactions as Key Elements in a N-Heterocyclic Carbene-Catalyzed [4+2] Cycloaddition" J. Am. Chem. Soc. 2012, 134, 12098–12103
- external page highlighted in CHIMIA 2012, 66, 801.

(66) Dumas, A. M., Molander, G. A., Bode, J. W. external page "Amide-Forming Ligation of Acyltrifluoroborates and Hydroxylamines in Water" Angew. Chem. Int. Ed. 2012, 51, 5683–5686.

(65) Dumas, A. M.; Bode, J. W. external page "Synthesis of Acyltrifluoroborates" Org. Lett. 2012, 14, 2138–2141.
- external page highlighted in Org. Process Res. Dev. 2012, 16, 1244–1257.

(64) Lyngvi, E.; Bode, J. W.; Schoenebeck, F. external page "A Computational Study of the Origin of Stereoinduction in NHC-Catalyzed Annulation Reactions of alpha,beta-Unsaturated Acyl Azoliums" Chem. Sci. 2012, 3, 2346–2350.

(63) Larson, K. K.; He, M.; Teichert, J. F.; Naganawa, A.; Bode, J. W. external page "Chemical Sensing with Shapeshifting Organic Molecules" Chem. Sci. 2012, 3, 1825–1828.
- external page highlighted in Nature Chem. 2012, 4, 336–337.

(62) Pattabiraman, V. R.; Ogunkoya, A. O.; Bode, J. W. external page "Chemical Protein Synthesis by Chemoselective α-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline" Angew. Chem. Int. Ed. 2012, 51, 5114–5118.
- external page selected as a Hot Paper & Cover.
- external page Corrigendum: Angew. Chem. Int. Ed. 2014, 53, 12005.

(61) Gerfaud, T.; Chiang, Y.-L.; Kreituss, I.; Russak, J.; Bode, J. W.; external page "Enantioselective, chromatography-free synthesis ofβ3-amino acids with natural and unnatural side chains" Org. Process Res. Dev. 2012, 16, 687–696.

(60) Fukuzumi, T.; Ju, L.; Bode, J. W. external page "Chemoselective Cyclization of Unprotected Linear Peptides by alpha-Ketoacid–Hydroxyamine Amide-Ligation" Org. Biomol. Chem. 2012, 10, 5837–5844.
- This article is part of the collection: Organic & Biomolecular Chemistry 10th Anniversary.

(59) Book chapter: Chiang, P.-C.; Bode, J. W. "N-Heterocyclic Carbene Catalyzed Reactions of alpha-Functionalized Aldehydes", Science of Synthesis: Asymmetric Organocatalysis, Vol. 1, 2012, Georg Thieme Verlag, 639–672. [Ed: B. List]

(58) Mahatthananchai, J.; Kaeobamrung, J.; Bode, J. W. external page "Chiral N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Stable Enols: A Highly Enantioselective Coates–Claisen Rearrangement" ACS Catal. 2012, 2, 494–503.
- external page Special issue on catalysis at ETH Zürich

(57) Pusterla, I.; Bode, J. W. external page "The Mechanism of the α-Ketoacid–Hydroxylamine (KAHA) Amide-Forming Ligation" Angew. Chem. Int. Ed. 2012, 51, 513–516.

(56) Mahatthananchai, J.; Bode, J. W. external page "The effect of the N-mesityl group in NHC-catalyzed reactions" Chem. Sci. 2012, 3, 192–197.

(55) Huang, Y.-L.; Frey, R; Juarez-Garcia, M. E.; Bode, J. W. external page "Synthesis of Aza-Surfactin and 3-Epi-aza-surfactin" Heterocycles 2012, 84, 1179–1191

(54) Review article: Pattabiraman, V.; Bode, J. W. external page "Rethinking Amide Bond Synthesis” Nature 2011, 480, 471–479.

(53) Binanzer, M.; Hsieh S.-Y.; Bode, J. W. external page "Catalytic Kinetic Resolution of Cyclic Secondary Amines" J. Am. Chem. Soc. 2011, 133, 19698–19701.
- external page reviewed in Synfacts 2012, 8, 211.

(52) Wanner, B.; Mahatthananchai, J.; Bode, J. W. external page "Enantioselective Synthesis of Dihydropyridinones via NHC-Catalyzed Aza-Claisen Reaction" Org. Lett. 2011, 13, 5378–5381.

(51) Schäfer, G.; Bode, J. W. external page "Friedel-Crafts Benzylation of Activated and Deactivated Arenes" Angew. Chem. Int. Ed. 2011, 50, 10913–10916.
- external page reviewed in Synfacts 2012, 8, 194.
- external page highlighted in Org. Process Res. Dev. 2012, 16, 526–534.
- external page highlighted in Organic Chemistry Portal.

(50) He, M.; Bode, J. W. external page "Racemization as a stereochemical measure of dynamics and robustness in shape-shifting organic molecules" Proc. Nat. Acad. Sci. U.S.A. 2011, 36, 14752–14756.

(49) Wu, J.; J. Ruiz-Rodríguez; Comstock, J. M.; Dong, J. Z.; Bode, J. W. external page "Synthesis of human GLP-1 (7–36) by chemoselective α-ketoacid–hydroxylamine peptide ligation of unprotected fragments" Chem. Sci. 2011, 2, 1976–1979.

(48) Vo, C.-V; Mitchell, T. A.; Bode, J. W. external page "Expanded Substrate Scope and Improved Reactivity of Ether-Forming Cross-Coupling Reactions of Organotrifluoroborates and Acetals" J. Am. Chem. Soc. 2011, 133, 14082–14089.
- external page highlighted in Organic Chemistry Portal.

(47) Perspective: Bode, J. W. external page "Organic Synthesis without Stoichiometric Reagents: A Guiding Principle for Reaction Development" Chimia 2011, 65, 150–156.

(46) Review article: Chiang, P.-C.; Bode, J. W. external page "N-Mesityl Substituted Chiral Triazolium Salts: Opening a New World of N-Heterocyclic Carbene Catalysis" TCI MAIL 2011, 149, 2–17.

(45) Chiang, P.-C.; Bode, J. W. external page "On the Role of CO2 in NHC-Catalyzed Oxidation of Aldehydes" Org. Lett. 2011, 13, 2422–2425.

(44) Mahatthananchai, J.; Zheng, P.; Bode, J. W. external page "α,β-Unsaturated Acyl Azoliums from N-Heterocyclic Carbene Catalyzed Reactions: Observation and Mechanistic Investigation" Angew. Chem. Int. Ed. 2011, 50, 1673–1677.

(43) Zheng, P.; Gondo, C. A.; Bode, J. W. external page "Late-Stage Diversification of Chiral N-Heterocyclic-Carbene Precatalysts for Enantioselectvie Homoenolate Additions" Chem. Asian J. 2011, 6, 614–620.

(42) Book chapter: Hackenberger, C. P. R.; Bode, J. W.; Schwarzer, D. external page "Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis" Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry, Volume 3 (ed A. B. Hughes), 2011.

(41) Review article: Chiang, P.-C.; Bode, J. W. external page "N-Heterocyclic Carbenes as Organic Catalysts" in N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools; Díez-González, S., Ed.; RSC Catalysis Series No. 6; Royal Society of Chemistry: Cambridge, 2011; pp 399–435. (DOI: 10.1039/9781849732161-00399)

(40) Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W. external page "Synthesis of Phototrappable Shape-Shifting Molecules for Adaptive Guest Binding" J. Am. Chem. Soc. 2010, 132, 15790–15799.

(39) Narumi, T.; Bode, J. W. external page "α,α-Dicholoroisoxazolidinones for the Synthesis and Chemoselective Peptide Ligation of α-Peptide α-Ketoacids" Heterocycles 2011, 82, 1515–1525.

(38) Kaeobamrung, J.; Kozlowski. M. C.; Bode, J. W. external page "Chiral N-Heterocyclic Carbene-Catalyzed Generation of Ester Enolate Equivalents from α,β-Unsaturated Aldehydes for Enantioselective Diels–Alder Reactions" Proc. Nat. Acad. Sci. U.S.A. 2010, 107, 20661–20665.

(37) Yu, S.; Ishida, H.; Juarez-Garcia, M. E.; Bode, J. W. external page "Unified synthesis of enantiopure β2h, β3h and β2,3-amino acids" Chem. Sci. 2010, 637–641.

(36) Kaeobamrung, J.; Mahatthananchai, J.; Zheng, P.; Bode, J. W. external page "An Enantioselective Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes" J. Am. Chem. Soc. 2010, 132, 8810–8812.
- external page reviewed in Synfacts 2010, issue 09, 1071.

(35) Struble, J. R.; Bode, J. W. external page "Synthesis of N-Mesityl Substituted Aminoindalnol-Derived Triazolium Salt [(5aS,10bR)-5a,10b-Dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride]" Org. Synth. 2010, 87, 362–376.

(34) Ju, L.; Bode, J. W. external page "Amide Formation by Decarboxylative Condensation of Hydroxyamines and α-Ketoacids: N-[(1S)-1-Phenylethyl]-benzeneacetamide" Org. Synth. 2010, 87, 218–225.

(33) Juarez-Garcia, M. E.; Yu, S.; Bode, J. W. external page "Asymmetric Synthesis of Enantiopure Isoxazolidinone Monomers for the Synthesis of β3-Oligopeptides by Chemoselective Amide Ligation" Tetrahedron 2010, 66, 4841–4853.

(32) Medina, S. I.; Wu, J.; Bode, J. W. external page "Nitrone Protecting Groups for Enantiopure N-Hydroxyamino Acids: Synthesis of N-Terminal Peptide Hydroxylamines for Chemoselective Ligations" Org. Biomol. Chem. 2010, 8, 3405–3417.

(31) Flores, M. A.; Bode, J. W. external page "Chemoselective Protection of α-Ketoacids by Direct Annulations with Oximes" Org. Lett. 2010, 12, 1924–1927.

(30) Mitchell, T. A.; Bode, J. W. external page "Synthesis of Dialkyl Ethers from Organotrifluoroborates and Acetal" J. Am. Chem. Soc. 2009, 131,18057–18059.
- external page reviewed in Synfacts 2010, issue 03, 335.

(29) Chiang, P.-C.; Kim, Y.; Bode, J. W. external page "Catalytic Amide Formation with α'-Hydroxyenones as Acylating Reagents" Chem. Commun., 2009, 4566–4568.
- external page reviewed in Synfacts 2009, issue 09, 1042.

(28) Chiang, P.-C.; Rommel, M.; Bode, J. W. external page "α'-Hydroxyenones as Mechanistic Probes and Scope-Expanding Surrogates for α,β-Unsaturated Aldehydes in N-Heterocyclic Carbene-Catalyzed Reactions" J. Am. Chem. Soc. 2009, 131, 8714–8718.

(27) Valenta, P.; Drucker, N. A.; Bode, J. W. and Walsh, P. J. external page "Simple One-pot Conversion of Aldehydes and Ketones to Enals" Org. Lett. 2009, 11, 2117–2119.

(26) Fukuzumi, T.; Bode, J. W. external page "A Reagent for the Convenient, Solid-Phase Synthesis of N-Terminal Peptide Hydroxylamines for Chemoselective Ligations" J. Am. Chem. Soc. 2009, 131, 3864–3865.

(25) Struble, J. R.; Bode, J. W. external page "Formal Synthesis of Salinosporamide A via NHC-catalyzed Intramolecular Lactonization" Tetrahedron, 2009, 65, 4957–4967.

(24) Ishida, H.; Carrillo, N.; Bode, J. W. "external page Synthesis of an enantiopure isoxazolidine monomer for β3-aspartic acid in chemoselective β-oligopeptide synthesis" Tetrahedron Lett. 2009, 50, 3258–3260.

(23) Ju, L.; Bode, J. W. external page "A general strategy for the preparation of C-terminal peptide a-ketoacids by solid phase peptide synthesis" Org. Biomol. Chem. 2009, 7, 2259–2264.

(22) Lippert, A. R.; Keleshian, V. L.; Bode, J. W. external page "Dynamic supramolecular complexation by shapeshifting organic molecules" Org. Biomol. Chem. 2009, 7, 1529–1532.

(21) Kaeobamrung, J.; Bode, J. W. external page "Stereodivergency of Triazolium and Imidazolium-Derived NHCs for Catalytic, Enantioselective Cyclopentane Synthesis" Org. Lett. 2009, 11, 677–680.

(20) Rommel, M.; Fukuzumi, T.; Bode, J. W. external page "Cyclic Ketimines as Superior Electrophiles for NHC-Catalyzed Homoenolate Additions with Broad Scope and Low Catalyst Loadings" J. Am. Chem. Soc. 2008, 130, 17266–17267.
- external page reviewed in Synfacts 2009, issue 02, 216.

(19) He, M.; Beahm, B. J.; Bode, J. W. external page "Chiral NHC-Catalyzed Oxodiene Diels−Alder Reactions with alpha-Chloroaldehyde Bisulfite Salts" Org. Lett. 2008, 10, 3817–3820.

(18) Struble, J. R.; Bode, J. W. external page "A modular synthesis of chiral aminoindanol-derived imidazolium salts" Tetrahedron 2008, 64, 6961–6972.

(17) Ju, L.; Lippert, A. R.; Bode, J. W. external page "Stereoretentive Synthesis and Chemoselective Amide-Forming Ligations of C-Terminal Peptide alpha-Ketoacids" J. Am. Chem. Soc. 2008, 130, 4253–4255.

(16) Struble, J.R.; Kaeobamrung, J.; Bode, J.W. external page "Synthesis of an N-Mesityl Substituted Chiral Imidazolium Salt for NHC-Catalyzed Reactions" Org. Lett. 2008, 10, 957–960.
- external page reviewed in Synfacts 2008, issue 06, 645.

(15) He, M.; Bode, J. W. external page "Enantioselective, NHC-Catalyzed Bicyclo-beta-Lactam Formation via Direct Annulations of Enals and Unsaturated N-Sulfonyl Ketimines" J. Am. Chem. Soc. 2008, 130, 418–419.
- external page reviewed in Synfacts 2008, issue 03, 307.

(14) Bode, J. W.; Sohn, S. S. external page "N-Heterocyclic Carbene-Catalyzed Redox Amidations of alpha-Functionalized Aldehydes with Amines" J. Am. Chem. Soc. 2007, 129, 13798–13799.

(13) Chiang, P.-C.; Kaeobamrung, J.; Bode, J. W. external page "Enantioselective, Cyclopentene-Forming Annulations via NHC-Catalyzed Benzoin–Oxy-Cope Reactions" J. Am. Chem. Soc. 2007, 129, 3520–3521.
- external page reviewed in Synfacts 2007, issue 05, 545.

(12) He, M.; Uc, G. J.; Bode, J. W. external page "Chiral, N-Heterocyclic Carbene Catalyzed Oxodiene Diels-Alder Reactions with Low Catalyst Loadings" J. Am. Chem. Soc. 2006, 128, 15088–15089.
- external page reviewed in Synfacts 2007, issue 01, 100.

(11) Review article: Bode, J. W. external page "Emerging Methods for the Synthesis of Amide and Peptide Bonds" Curr. Opin. Drug Discov. Devel. 2006, 9, 765–775.

(10) Lippert, A. R.; Kaeobamrung, J.; Bode, J. W. external page "Synthesis of Oligosubstituted Bullvalones: Shapeshifiting Molecules Under Basic Conditions ", J. Am. Chem. Soc. 2006, 128, 14738–14739.

(9) Sohn, S. S.; Bode, J. W. external page "N-Heterocyclic Carbene Catalyzed C–C Bond Cleavage in Redox Esterifications of Chiral Formylcyclopropanes" Angew. Chem. Int. Ed. 2006, 6021–6024.
- external page reviewed in Synfacts 2006, issue 10, 1060.

(8) He, M.; Struble, J. R.; Bode, J. W. external page "Highly Enantioselective Azadiene Diels-Alder Reactions Catalyzed by Chiral N-Heterocyclic Carbenes" J. Am. Chem. Soc. 2006, 128, 8418–8420.
- external page reviewed in Synfacts 2006, issue 08, 840.

(7) Carrillo, N.; Davalos, E. A.; Russak, J. A.; Bode, J. W. external page "Iterative, Aqueous Synthesis of b3-oligopeptides without Coupling Reagents" J. Am. Chem. Soc. 2006, 128, 1452-1453.external page
- external page highlighted in C&E News.

(6) Bode, J. W.; Fox, R. M.; Baucom, K. D. external page "Decarboxylative Condensations of alpha-Ketoacids and N-Alkylhydroxylamines: A New Amide Ligation Reaction" Angew. Chem. Int. Ed. 2006, 45, 1248-1252.
- external page highlighted in C&E News.

(5) Sohn, S.; Bode, J. W. external page "Catalytic Generation of Activated Carboxylates from Enals: A Product Determining Role for the Base" Org. Lett. 2005, 7, 3873-3876.external page
- external page categorized in Organic Chemistry Portal.

(4) He, M.; Bode, J. W. external page "Catalytic Synthesis of gamma-Lactams via Direct Annulations of Enals and N-Sulfonylimines" Org. Lett. 2005, 7, 3131–3134.
- external page highlighted in Angew. Chem. Int. Ed. 2005, 44, 7506.

(3) Bode, J. W. external page "Reactor, Chem Axon" J. Am. Chem. Soc. 2004, 126, 15317. (Software Review)

(2) Sohn, S. S.; Rosen, E. L.; Bode, J. W. external page "N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: gamma-Butyrolactones by Direct Annulations of Enals and Aldehydes" J. Am. Chem. Soc. 2004, 126, 14370-14371.
- external page highlighted in Angew. Chem. Int. Ed. 2005, 44, 7506.

(1) Chow, K. Y.-K.; Bode, J. W. external page "Catalytic Generation of Activated Carboxylates: Direct, Stereoselective Synthesis of beta-Hydroxyesters from Epoxyaldehydes" J. Am. Chem. Soc. 2004, 126, 8126–8127.
- external page highlighted in Angew. Chem. Int. Ed. 2005, 44, 7506.